Tuesday, July 26, 2011

Natural Approaches to Endometriosis

What is Endometriosis?

Endometriosis is a medical condition characterized by growth of tissue similar to that lining the uterus, the endometrium, in areas of the body beyond the uterus. The displaced tissue may respond to the monthly cycle just as the endometrium does. However, at the last phase of the woman's cycle, the shed 'endometrium-like' tissue grown outside of the uterus, cannot be eliminated as menstrual bleeding through the natural channel of exit. This leads to the build up of plaques or lesions which worsen over time. 

Endometriosis lesions can affect female pelvic cavities, the Fallopian tubes, ovaries, the pelvic-side wall, ligaments beneath the ovaries, utero-sacral ligaments and the rectal vaginal septum. Less commonly, they can be found on the bladder, intestines, ureters, diaphragm, rarely  on the skin, lung, spine and brain.

As an estrogen dependent condition, usually affects women in reproductive age. However, it can also occur in post-menopausal women with an estimated incidence of 2-4%. Women having an affected first-degree relative show a 10 fold increased incidence of developing the condition. The most common symptom of Endometriosis is severe, recurring pelvic pain, which may or may not be correlated to the menstrual cycle and whose intensity is not necessarily related to the extent or stage of Endometriosis. For many women the pain can be so severe and debilitating to impact their lives in significant ways. Women diagnosed with Endometriosis may present gastrointestinal symptoms mimicking Irritable Bowel Syndrome and may also suffer from Depression and Fatigue.

It's estimated that 30-40% of women with Endometriosis show infertility. In some women, this condition is only discovered after fertility investigations. However, Endometriosis-related infertility is often treated successfully with surgery. Although extensive Endometriosis can distort pelvic anatomy and thus partly explain infertility, the relationship between infertility and Endometriosis is not yet clear and therefore actively investigated.

The only sure method to confirm an Endometriosis diagnosis is by laparoscopy, which also treats the condition. Although there's presently no cure, treatment options exist. Patients can be treated with birth control pills, hormone therapies, drugs inducing menopause, even hysterectomy to stop the dysmenorrheal symptoms. Hysterectomy, though, cannot ensure disappearance of symptoms, for the possibility of adhesions on other organs beside the reproductive organs and even on the abdominal wall. 

Aspirin-like, pain-killer medications, such as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) are commonly used. However, both, NSAIDs and hormonal treatment on a long run can also be the cause of a number of adverse-side effects, which worsen the condition. 

Medical herbal treatments have also been proved effective. Traditional Chinese Medicine (TCM) approaches differently the causes of Endometriosis. In TCM, it is classified as a liver disorder associated with liver stagnation. Recent studies have indeed supported this theory and implicated chronic exposure to environmental pollutants, as dioxins, to liver problems and Endometriosis, independently. A compromised liver also contributes to weakening the immune system, a factor implicated in Endometriosis.

The Herbal ingredients used in TCM for the treatment of Endometriosis work primarily by affecting the functioning of the liver and of the female reproductive system. Among the hormone-balancing herbs, widely used are Chaste Berry and Don Quai. Particularly effective for liver problems is the herb named Milk Thistle. Chinese Yam is used for his excellent tonic properties on the liver and nervous system and for its anti-inflammatory properties. An homeopathic remedy named Viburnum opulus has been proved effective too, especially for backache associated with Endometriosis.

Endometriosis must not be confused with Endometrial Cancer. However, it has been hypothesized that the excess estrogen production by Endometriosis may eventually cause ovarian or other cancers over a woman's life time. The staging of endometriosis resembles the staging of cancer. 

For more info, studies and publications visit www.endometriosis.org
ps. Always keep in mind that You are strongly advised to consult healthcare specialists and your own family medical doctor, before implementing any change to your diet or following any medical advice. The information presented here or anywhere else online is uniquely provided with the purpose to inform You, so that You can act on and take informed decisions for improving your health

Monday, July 04, 2011

Latest News on Telomeres and Life Expectancy



The END of Chromosomes determines the END of our life. But is it really true?

News of last May about the possibility to know the end of our life testing the ends of our chromosomes have raised lots of rumor. As reported in the Independent on May 16th, by the end of this yearpaying roughly 500 Euros, through a simple and specific blood test in England, it will be possible to know how long we can yet live. As expected, ethical controversies about this matter are on the rise.  

More precisely, the test should allow to understand the 'biological age' of a person, as measured by the length of a person's telomeres, the terminal part of our chromosomes. Actually, the test will establish if our 'biological age' is higher or lower than our 'chronological age'. According to the Medical community, in the next years, telomeres tests promise to be even more developed and perfected.


Needless to say, knowing the 'real age' will have a profound impact on a person's life and alarming could be the speculations of life-insurance companies, unscrupulous employers and profit-oriented companies proposing anti-age remedies with little or none scientific foundation.The wisest front of the Scientific Community, however,  invokes the urgency of control systems to prevent useless dramas and unethical behavior and practices.


On the other hand, by the same admission of Maria Blasco, the Scientist at the National Cancer Research Center in Madrid, who proposed the Telomeres Test, not much is known on humans so to warrant secure answers to life expectancy. In the interview appeared in the Independent on May 16th, she affirmed that, although it's known that individuals born with telomeres shorter than normal also have a lower life expectancy, it's not known, however, if longer telomeres are also associated with longer life expectancy. At least, it is not  well known for humans.

The real novelty of the test proposed by her through her Company, Life Lenght, is the precision by which even the smallest differences can be detected easily, rapidly and analyzing simultaneously several samples. More importantly, the Company claims to be able to detect  the presence of really dangerous telomeres, the very short ones. Right now, Life Lenght is in contact with important Diagnostic Centers in all Europe to collect blood samples which will be analyzed in Spain.  Agreements with a Company operating in the United Kingdom should be reached in one year. At the present moment, Life Lenght is the only company selling the test without need of medical prescription. 

Prof Jerry Shay, at the University of Texas Southwestern Medical Center, in Dallas, as reported in the same article in the Independent, underlies the importance of the Biological Age and how Telomeres length can give a good representation of it.

Personally, I believe that even though, the test may facilitate Research on Telomeres length in humans and in understanding its implications in human health,  it's hazardous to advance more hypotheses on life expectancy, before more precise strategies of association will be designed and investigated. I could also see how eventual statistical data may be affected by the emotional impact that a telomeres test response may have on a person's life. For example, if an individual received the undesirable response to have telomeres shorter than normal, how much more depressed he/she will feel because of the bad news, and how much worse will he/she  live? Probably, even at the point to shorten his/her life expectancy. Would not that be true?


So why not live to the full uncaring of our telomeres length? Even more so now that Epigenetic Research seems to strongly suggest that not all is written on our DNA genes, that is on our chromosomes and therefore less than ever on our chromosome ends, the telomeres. Let's give time to Research to discover more in this arena before burden ourselves with useless weight or 'lengths'.


To know more on Telomeres and the latest news, visit:
http://www.wallstreetitalia.com/article/1132809/quanto-vi-rimane-da-vivere-ve-lo-dira-un-test-al-costo-di-500.aspx
http://learn.genetics.utah.edu/content/begin/traits/telomeres/
http://wmbriggs.com/blog/?p=3905